Antibiotic Use May Damper the Efficacy of Checkpoint Inhibitors

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"Use of antibiotics up to a month before treatment with a checkpoint inhibitor may decrease the efficacy of the immunotherapy agent, results of a retrospective analysis show. The analysis, presented during a presscast of the 2017 Genitourinary Cancers Symposium, raised suspicion of the relationship between gut microbiota and antibiotics and their effect on immune checkpoint blockade agents.1

"In patients with metastatic renal cell carcinoma (mRCC), patients who had received broad-spectrum antibiotics had a shorter median progression-free survival (PFS) rate when treated with checkpoint inhibitor immunotherapy than those who had not received antibiotics of 2.3 versus 8.1 months, respectively (P <.001). "

http://www.onclive.com/conference-cover ... inhibitors

“Immune based therapies for cancer may have a complex interplay with the host’s microbiome,” commented Pal, an assistant clinical professor in the Department of Medical Oncology and Therapeutics Research and co-director of the Kidney Cancer Program at City of Hope in Duarte, California. Antibiotics may influence the bacterial composition of our gut, and this could in turn impact how effective immune therapy is” - See more at: http://www.onclive.com/conference-cover ... OG2h1.dpuf

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Outlook
Research
The five-year survival rates of renal cell carcinoma vary greatly depending on which stage you’re diagnosed with. According to the American Cancer Society, the five-year survival rates for kidney cancer are as follows:

stage 1: 81%
stage 2: 74%
stage 3: 53%
stage 4: 8%
Looks like 80% of the patients were in 1,2 stage 3 during the trial ? And were without a kidney
And the cancer is asymtomatic till later stages..
Not unlike Asps

http://www.healthline.com/health/metast ... a#Outlook8

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"Surgery for Metastatic Renal Cell Cancer. For patients with Stage IV disease whose cancer has spread locally, but not to distant sites in the body, radical nephrectomy may be curative. ... Systemic (whole-body) treatments, such as targeted therapy and immunotherapy, can treat cancer that has spread throughout the body.
Stage IV Renal Cancer | Texas Oncology
Texas Oncology › types-of-cancer › stag..."


https://www.texasoncology.com/types-of- ... al-cancer/


There were several patients ,in Germany, with mRCCwho were using Dr Rolles lung surgeries as I recall.

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Having had a kidney
And or kidney adrenal gland etc removed, these folks sure were compromised with , for lack of a better word, a complete systemic of checks and balances to deal with infections ?


"Kidney removal"

https://medlineplus.gov/ency/article/003001.htm

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Study
2014 in mice


Emerging roles of the microbiome in cancer.

"The human microbiota includes bacteria, fungi, archaea and viruses. Micro-animals which live on the human body are excluded. The human microbiome refers to their genomes.
Microbiota - Wikipedia
Wikipedia › wiki › Microbiota"


https://www.ncbi.nlm.nih.gov/m/pubmed/2 ... 92/related

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Negative association of antibiotics on clinical activity of immune checkpoint inhibitors in patients with advanced renal cell and non-small-cell lung cancer


https://academic.oup.com/annonc/article ... m=fulltext