Please don't let the fact that it was written in 1994 loose its importance in your eyes.
Neurosurgery:Volume 35(2)August 1994p 185-191
Sarcoma Metastatic to the Brain: Results of Surgical Treatment
[Clinical Study]
Bindal, Rajesh K. B.A.; Sawaya, Raymond E. M.D.; Leavens, Milam E. M.D.; Taylor, Sarah H. M.P.H.; Guinee, Vincent F.
M.D., M.P.H.
Departments of Neurosurgery (RKB, RES, MEL) and Patient Studies (SHT, VFG), The University of Texas M. D. Anderson Cancer
Center, Houston, Texas
Reprint requests: Raymond Sawaya, M.D., Department of Neurosurgery, The University of Texas M. D. Anderson Cancer Center,
1515 Holcombe Boulevard, Box 64, Houston, TX 77030.
Received, December 22, 1993. Accepted,
February 23, 1994.
ABSTRACT TOP
http://www.texasspineandneurosurgerycen ... ets_94.pdfBrain metastasis is a common
complication of systemic cancer, with 15
to 20% of all patients dying of cancer
developing brain metastases 2,4. Brain
metastasis from sarcoma is a rare event.
Overall, 1 to 8% of patients with sarcoma of various histologies develop intraparenchymal brain metastases
3,7,13,22,24,37,44. The only exception is in patients with alveolar soft-part sarcoma (ASPS) in whom the incidence is 33%
27. Use of chemotherapy is thought to increase the incidence of brain metastasis secondary to improving systemic control of
the disease and to failure of many chemotherapeutic agents to cross the blood-brain barrier 13,15,16. Nevertheless, brain
metastasis from sarcoma is rare and, as a result, there is no report in the literature of the results of treatment in a series of
patients.