local anesthetics may provide beneficial antimetastatic ...

[Amanda]

http://www.ncbi.nlm.nih.gov/pubmed/22846676

Antimetastatic potential of amide-linked local anesthetics: inhibition of lung adenocarcinoma cell migration and inflammatory Src signaling independent of sodium channel blockade.
Piegeler T1, Votta-Velis EG, Liu G, Place AT, Schwartz DE, Beck-Schimmer B, Minshall RD, Borgeat A.
Author information
Abstract
BACKGROUND:
Retrospective analysis of patients undergoing cancer surgery suggests the use of regional anesthesia may reduce cancer recurrence and improve survival. Amide-linked local anesthetics have antiinflammatory properties, although the mechanism of action in this regard is unclear. As inflammatory processes involving Src tyrosine protein kinase and intercellular adhesion molecule-1 are important in tumor growth and metastasis, we hypothesized that amide-linked local anesthetics may inhibit inflammatory Src-signaling involved in migration of adenocarcinoma cells.
METHODS:
NCI-H838 lung cancer cells were incubated with tumor necrosis factor-α in absence/presence of ropivacaine, lidocaine, or chloroprocaine (1 nM-100 μM). Cell migration and total cell lysate Src-activation and intercellular adhesion molecule-1 phosphorylation were assessed. The role of voltage-gated sodium-channels in the mechanism of local anesthetic effects was also evaluated.
RESULTS:
Ropivacaine treatment (100 μM) of H838 cells for 20 min decreased basal Src activity by 62% (P=0.003), and both ropivacaine and lidocaine coadministered with tumor necrosis factor-α statistically significantly decreased Src-activation and intercellular adhesion molecule-1 phosphorylation, whereas chloroprocaine had no such effect. Migration of these cells at 4 h was inhibited by 26% (P=0.005) in presence of 1 μM ropivacaine and 21% by 1 μM lidocaine (P=0.004). These effects of ropivacaine and lidocaine were independent of voltage-gated sodium-channel inhibition.
CONCLUSIONS:
This study indicates that amide-, but not ester-linked, local anesthetics may provide beneficial antimetastatic effects. The observed inhibition of NCI-H838 cell migration by lidocaine and ropivacaine was associated with the inhibition of tumor necrosis factor-α-induced Src-activation and intercellular adhesion molecule-1 phosphorylation, providing the first evidence of a molecular mechanism that appears to be independent of their known role as sodium-channel blockers.

[D.ap]

Amanda

How cool is that to know a possible method to disrupt the metastisis.
If you don't mind I found an article on cells signaling and or functions.It explains within the article , why on a cellar basis the process goes wrong= cancer
The article as stated touches on some of the major players as far as cells go. Receptors etc.
Which if not for cells the anesthesia couldn't work period.

http://users.rcn.com/jkimball.ma.ultran ... aling.html

Also an in depth article on anesthesia


http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1693664/

Have a beautiful day.

Love
Debbie

[Amanda]

Hi
I was looking at this and then started to read a little more on other things like the use or NORCO... an i found out thru two places that NORCO may not be good for stage four cancer patients it may make it spread faster :/
I am looking at it a little more and will when i get back from camping. But, it is the opiate an receptors in cancer.. Seems cancer cells have more receptors than normal cells an it in the research i was looking at it points to a higher rate of spread in stage 4 patients!

I know its not the new england journal.. but this scarred me to be honest it does mage logical sence http://www.uchospitals.edu/news/2012/20 ... pioid.html
I have lung mets and i use NORCO an it started to grow around the time when i started to use NORCO...
It maybe a fluke *shrugs*

I need to not use it now anyhow and i hate it to be honest so i will look at CBN's thru a doctor in los angeles.
If anyone knows of a naturopath in Ca Los Angeles or west sime please let me know

[D.ap]

Hi Amanda

Didn't pickup what CBN's were ?
What is your goal with an ND?
Just got back from trip myself and wanted to touch base.
I've forwarded the link to a close friend and you might want to do so with your Onc as well.

Good to hear from you
Safe camping and have fun!
Love
Debbie

[D.ap]

Hey Amanda

I hope you had a great time camping.
I love camping and fishing. It soothes the soul doesn't it ?
I got a response from my person on what she thought about the article on lung cancer possibly being exasperated by opioids during the anesthesia phase of surgery ?
Her response is as follows -


Hi Deb
Sorry I just now saw this. The thing you always want to remember is Josh isn't dealing with lung cancer - he's dealing with sarcoma in his lungs. The article was focused on mu receptors and lung cancer. I didnt read the whole article but I wouldnt be too concerned Bout this.

Have a beautiful day , Amanda .

Love
Debbie

[Amanda]

Hi and thank you!
I was concerned in reference to NORCO use i use it as a pain killer since i am a patchwork doll now...

I was told and can't remember where that the mets in the lungs hated the anesthesia and it can hurt or slow the mets.. i wish i could remember who told me that lol Anyhow, thank you so much for reaching out an getting that reply and posting it to me <3