Cabozantinib might be (possible) used to treat bone mets

[Olga]

It is hard to sat what role Cabozantinib might have in ASPS treatment since there are no clinical trials done in ASPS - would it be only active in increasing progression free survival without actually increasing the overall survival (as it was found in the Phase 3 for thyroid cancer) or the result will be better? Or it might be used to reduce the size of the unresectable metastases to a point when they are treatable by the ablation/resection etc?
Getting the drug off label versus a clinical trial has its benefits as it allows more flexibility in a treatment planning.
I found an interesting fact in an article
http://www.ncbi.nlm.nih.gov/pubmed/23292795
Cabozantinib as a novel therapy for renal cell carcinoma.
that they observed "Dramatic responses in bone metastases" using Cabozantinib, it is very rare that bone metastases respond at all to any treatment and might be a reasonable option for the patients with unresectable bone mets. But make sure that there are no occult brain metastases as sudden bleeding might happen if the drug is active and there are untreated brain mets, check you brain before you start this treatment and treat any known brain mets by the readily available radiosurgery or open surgery before.