If you had a response to Votrient and started to progress
Posted: Mon Aug 05, 2013 7:35 pm
I am reposting this from the LMS sarcoma mailing list - someone reposted it on sarcoma mailing list and I find it a very good info to be shared:
Subject: Lynda's results of new Votrient-rapamune combination
Hi, listmates.
I have talked with some of you previously about my results while on
Votrient and promised an update when I had my new scans, so here it is.
I have been on 800 mg/day of Votrient since last Oct. For the first 6
months I had skrinkage, then in my March scans several nodules started
showing some growth. On the advice of Dr. Chmielowski at UCLA, in May we
added 4 mg/day of rapamune to my program because he had been seeing some
good results with this combo.
For me this has really worked. I had new scans last week and have no new
growths and all existing mets have had a reduction in SUV (glucose) uptake.
Some of the nodules decreased their uptake by 50%. This, for me, is
tremendously good news and I am continuing this combination for now. I
will have new scans just before Thanksgiving.
The side effects from this combo of " targeted therapies" have not been bad
and I have a pretty good quality of life. I have had fatigue and diarrhea,
sensitivity to the sun, easy bruising, sinus drainage, sense of taste has
changed, hair turned white. I have NOT had liver, kidney, or heart
problems.
For those who have been on Votrient for awhile with good success, and now
are seeing growth, you may see good results from adding rapamune to your
program. If your oncologist is not familiar with this, they could probably
contact Dr. Chmielowski.
My comment:
Rapamune (sirolimus) is an MTor inhibitor. There is already a documented report posted here by Johannes:
From ASCO 2013: response to Pazopanib+mTOR inhibitor in STS
Post by Johannes ยป Sat Jun 08, 2013 4:39 pm
Reversal of acquired resistance to pazopanib in soft tissue sarcoma with addition of an mTOR inhibitor: A case report.
http://www.cureasps.org/forum/viewtopic.php?f=3&t=804
The known side effects of adding sirolimus are different, some of them are very serious (pneumonitis, immunosupression - viral infections etc.) so evaluate your options carefully based on your overall health condition.
Subject: Lynda's results of new Votrient-rapamune combination
Hi, listmates.
I have talked with some of you previously about my results while on
Votrient and promised an update when I had my new scans, so here it is.
I have been on 800 mg/day of Votrient since last Oct. For the first 6
months I had skrinkage, then in my March scans several nodules started
showing some growth. On the advice of Dr. Chmielowski at UCLA, in May we
added 4 mg/day of rapamune to my program because he had been seeing some
good results with this combo.
For me this has really worked. I had new scans last week and have no new
growths and all existing mets have had a reduction in SUV (glucose) uptake.
Some of the nodules decreased their uptake by 50%. This, for me, is
tremendously good news and I am continuing this combination for now. I
will have new scans just before Thanksgiving.
The side effects from this combo of " targeted therapies" have not been bad
and I have a pretty good quality of life. I have had fatigue and diarrhea,
sensitivity to the sun, easy bruising, sinus drainage, sense of taste has
changed, hair turned white. I have NOT had liver, kidney, or heart
problems.
For those who have been on Votrient for awhile with good success, and now
are seeing growth, you may see good results from adding rapamune to your
program. If your oncologist is not familiar with this, they could probably
contact Dr. Chmielowski.
My comment:
Rapamune (sirolimus) is an MTor inhibitor. There is already a documented report posted here by Johannes:
From ASCO 2013: response to Pazopanib+mTOR inhibitor in STS
Post by Johannes ยป Sat Jun 08, 2013 4:39 pm
Reversal of acquired resistance to pazopanib in soft tissue sarcoma with addition of an mTOR inhibitor: A case report.
http://www.cureasps.org/forum/viewtopic.php?f=3&t=804
The known side effects of adding sirolimus are different, some of them are very serious (pneumonitis, immunosupression - viral infections etc.) so evaluate your options carefully based on your overall health condition.