Low Iodine Diet to lower your thyroids naturally

[Olga]

There is a new article linking cancer progression and chemoresistance to thyroid hormone (we have already noted before that when we see the response to TKI and other treatments, it is often accompanied by the low thyroid hormone levels and that it might be not in the cancer treatment interest to try to keep it normal or high, rather on a lowest normal level):

PD-L1 and PD-1 gene expression are both stimulated by thyroid hormone in cancer cells
https://www.omicsonline.org/proceedings ... 63406.html

"We have shown that thyroid hormone (L-thyroxine, T4) at physiological concentrations acts non-genomically to stimulate cancer cell proliferation, to block apoptosis and to stimulate tumor-related angiogenesis. We report here that T4 stimulates PD-L1 gene expression by a mechanism that is initiated at the cell surface receptor for T4 on the extracellular domain of plasma membrane integrin αvβ3."
T4 stimulates PD-L1 gene expression directly, surpassing the PD-1, so blocking PD-1 will not interfere with T4 stimulation of the PD-L1. If you are on a PD-1 antibody with the goal of blocking PD-L1, avoiding a stimulation of the PD-L1 with the thyroid hormone directly might be beneficial.

The study was done in a dish, not in humans. But it rises a warning flag, that it might be more important for the cancer patients versus general public to avoid the food that increases the thyroid level more than it is currently recommended at 150 mcg/per day. With the iodized table salt, high content if iodine in milk (due to sanitary practices involving iodine, less in organic milk by 20-30% but with the big variability), high iodine salt content in commercially cooked products and use of iodine in the washing preparation of the greens for the sale - it is easy to over consume iodine past the recommended dose, therefore overstimulating thyroid. There is currently a concern not re. people getting not enough but to much of it.

American Thyroid association calls this type of diet a Low Iodine Diet (the list is given for the people preparing for the thyroid cancer treatment when they need to deplete the iodine in order for it to succeed so there is a different level of urgency to completely avoid these foods, we can just use it as a reference to avoid having a higher than normal level).
https://www.thyroid.org/low-iodine-diet/
Summary:
• No iodized salt
• No dairy products or foods containing dairy products
• No foods from the sea
• Limited grain products (ie noodles, pasta, pastries) – 1 slice bread, ½ cup pasta daily
• Limited amounts of beef, chicken and turkey

AVOID THE FOLLOWING FOODS

Iodized salt
Any vitamins or supplements that contain iodine (especially kelp and dulse)
Milk or other dairy products including ice cream, cheese, yogurt and butter
Seafood including fish (esp.cod), sushi, shellfish, kelp or seaweed
Herbal supplements
Foods that contain the additive carrageen, agar-agar, alginate, or nori
Commercially prepared bakery products that are made with iodate dough conditioners
FD&C red dye #3 – this appears in maraschino cherries and occasionally as a pink/red artificial color in beverages
Egg yolks, whole eggs and foods containing whole eggs
Milk chocolate (due to dairy content)
Blackstrap Molasses (unsulfured molasses is fine)

The levels of the iodine in different foods varies so we need to see where they are at the highest - I suspect that the iodized salts, seaweed and supplements will lead the way, but we need to verify. For example in a fish department there is a big difference - the cod is high in iodine while other ones are very moderate. Feel free to check and post what you see relevant.
The full list sorted by the iodine level is here so you can check the iodine amounts and what food is in the highest/middle/lowest content:
http://frida.fooddata.dk/ShowList.php?compid=163

In addition to avoiding or limiting the consumption of high-iodine foods, the other strategy is based on anti-iodine foods that may reduce the iodine absorption - so called Goitrogens - the substances that disrupt the production of thyroid hormones by interfering with iodine uptake in the thyroid gland. Eaten in large quantities and without other food, they might cause an abnormal growth in the thyroid gland, but normally they will just reduce thyroid function a bit. These compounds are primarily found in cruciferous vegetables, such as cabbage, Brussels sprouts, broccoli, broccolini, cauliflower, mustard greens, kale, turnips, and collards. In addition Isothiocyanates, like soy isoflavones, appear to block TPO, and they may also disrupt signaling across the thyroid's cell membranes.