Pulmonary toxicity of the gemcitabine
Posted: Fri Mar 27, 2009 8:26 am
I am also looking up possible side effects to Gemzar so we can be aware of this.
There is a pulmonary toxicity associated with Gemzar which might be like an allergic reaction. The incidence seems to be 5-10%. When detected early, Gemzar stopped, and high dose steroids begun, the process seems to be completely reversible. But importantly, the paper (link below) suggested that patients with prior lung resections / surgery may have less lung reserve and be more vulnerable. This allergic reaction usually occurs after weeks to months on the drug, but rarely it can occur after a single dose. Because this is a reversible process - this is pulmonary toxicity rather than pulmonary fibrosis. Drugs like Tarceva can cause irreversible pulmonary fibrosis.
http://www.smw.ch/docs/pdf200x/2002/01/smw-09893.PDF
There is a pulmonary toxicity associated with Gemzar which might be like an allergic reaction. The incidence seems to be 5-10%. When detected early, Gemzar stopped, and high dose steroids begun, the process seems to be completely reversible. But importantly, the paper (link below) suggested that patients with prior lung resections / surgery may have less lung reserve and be more vulnerable. This allergic reaction usually occurs after weeks to months on the drug, but rarely it can occur after a single dose. Because this is a reversible process - this is pulmonary toxicity rather than pulmonary fibrosis. Drugs like Tarceva can cause irreversible pulmonary fibrosis.
http://www.smw.ch/docs/pdf200x/2002/01/smw-09893.PDF