There is an ongoing discussion about using TKI - when to use them and how to stop them with no harm to patient due to a concern about possible rebound growth at the higher speed.
There is a new study done by the Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center, Amsterdam looking at the effect of discontinuation of treatment with one of the tyrosine kinase inhibitors Sunitinib in the renal cell carcinoma patients. They observed a rapid angiogenesis onset after discontinuation of Sunitinib treatment of Renal Cell Carcinoma patients.
Rapid angiogenesis onset after discontinuation of sunitinib treatment of renal cell carcinoma patients.
http://www.ncbi.nlm.nih.gov/pubmed/22573349
free version of the article is avail. on the Pubmed abstract page with the link on the upper right.
What could happen if the TKI is stopped (if it worked)
Warning about rebound effects when stopping VEGF inhibitors
I am unable to post this to the main TKI category. I think it would be more relevant there--Olga could you move this unless you think it belongs here.
http://clincancerres.aacrjournals.org/c ... /3719.full
http://clincancerres.aacrjournals.org/c ... /3719.full
Re: What could happen if the TKI is stopped (if it worked)
I fixed the permissions in this forum, you should be able to post now, let me know if not.
Olga