Cure Alveolar Soft Part Sarcoma International (iCureASPS)

“The reaction, discovered in 2017 after four years of research in mice, has been described as a "runaway train" where one error leads the body to develop a very efficient way of attacking itself. The study focussed on B cells gone rogue. Ordinarily these cells produce antibodies and progr...

Key Points Following immunization, CD4+ T cells promote the induction of a robust primary CD8+ T cell response through numerous mechanisms, including licensing of dendritic cells (DCs) and promoting the interaction between DCs and CD8+ T cells. CD4+ T cells regulate the secondary responsiveness of ...

Cont.. Introduction The heterogeneity of human cancers combined with the diversity of mechanisms acting in concert within established tumors to suppress the immune response make it unlikely that any single-agent immunotherapy will elicit meaningful tumor regression in a majority of patients—an expec...

Tackling the Conundrum of Cachexia in Cancer cont… The researchers in Cambridge, led by M.D.-Ph.D. student Thomas R. Flint and oncologist Tobias Janowitz, M.D., Ph.D., performed experiments demonstrating that in mouse models of pancreas and colon cancer, liver reprogramming begins during pre-cachexi...

One of the worst cruelties of lethal cancer is the phenomenon called wasting, or in medical terms, cachexia (pronounced ka-CHEX-ia), in which a patient seems literally to diminish in bodily terms as the cancer ravages one or more internal organs. Today, a team at Cancer Research UK Cambridge Institu...

Keto diets shrink pancreatic and colorectal tumors by starving them of the glucose they need to survive. But they also speed up development of a lethal wasting disease called cachexia. In mice, CSHL researchers have found that pairing keto with a corticosteroid prevents cachexia and increases surviv...

Yes, Deb, this is why I always feel uneasy when we start to discuss the popular anticancer diets here - they often associated with the weight loss for the patient and in the long run it is unknown if the dieting brings an overall benefit or harms the patient - considering that many of the cancer pa...

D.ap wrote: ↑Sun Sep 28, 2014 7:05 am For those of you who are up to the challenge
A look at cachexia on the physiological view

http://physrev.physiology.org/content/89/2/381

Olga please delete above post !

“ Leptin is an adipokine with central importance in the global obesity problem and consequent cardiovascular disease and is principally secreted by adipocytes and acts in the hypothalamus to suppress appetite and food intake, increase energy expenditure, and regulate body weight.” https://cureasps.o...

It’s interesting to note that in 2015 we also had a non responsive brain tumor that was treated by LITT, after an unsuccessful SRS treatment. In reading about cachexia there seems to be some association to traumatic brain injuries and hormones , that can be triggered by that event . My limited under...

Feb 11,2017 Good morning all Josh had his 15th infusion on Thursday and weighted in at a wapping 127.2 lbs! His sleep patterns are still skewed but he is working on creating normal schedules with his day . Getting back to NORMAL is so challenging as you all can attest to today Last year at this time...

A Case Report of Reversal of Cancer Cachexia and Literature Review Huaixing M*, Li P and Suyi L Department of Oncology Nutrition and Metabolic Therapy, The First Affiliated Abstract Cancer cachexia, as a special malnutrition, has poor efficacy with nutritional support alone. Patients with cachexia ...

Biology of Cachexia Abstract About half of all cancer patients show a syndrome of cachexia, characterized by loss of adipose tissue and skeletal muscle mass. Such patients have a decreased survival time, compared with the survival time among patients without weight loss, and loss of total body prote...

Bone Metastasis and Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer (NSCLC): Microenvironment and Possible Clinical Implications Abstract Patients with non-small cell lung cancer (NSCLC) develop bone metastasis (BoM) in more than 50% of cases during the course of the disease. This metast...

Abstract Radiation therapy (RT) continues to play a central role as an effective therapeutic modality for a variety of tumors and vascular malformations in the central nervous system. Although the planning and delivery techniques of RT have evolved substantially during the past few decades, the stru...