Search found 4017 matches
- Thu May 30, 2024 6:39 am
- Forum: Other Publications
- Topic: Study reveals first evidence inherited genetics can drive cancer’s spread
- Replies: 2
- Views: 1523
Re: Study reveals first evidence inherited genetics can drive cancer’s spread
There are three types of the APOE gene, called alleles: APOE2, E3 and E4. Everyone has two copies of the gene and the combination determines your APOE "genotype"—E2/E2, E2/E3, E2/E4, E3/E3, E3/E4, or E4/E4. Apolipoprotein (apo) E is a multifunctional protein with central roles in lipid me...
- Wed May 29, 2024 4:23 pm
- Forum: Other Publications
- Topic: Study reveals first evidence inherited genetics can drive cancer’s spread
- Replies: 2
- Views: 1523
Re: Study reveals first evidence inherited genetics can drive cancer’s spread
Common germline variants of the human APOE gene modulate melanoma progression and survival Abstract Common germline variants of the APOE gene are major risk modifiers of neurodegenerative and atherosclerotic diseases1,2,3, but their effect on cancer outcome is poorly defined. Here we report that, in...
- Sun May 26, 2024 6:06 pm
- Forum: Medical Publications
- Topic: ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops around hexameric VCP/p97
- Replies: 0
- Views: 84
ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops around hexameric VCP/p97
ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops around hexameric VCP/p97 07 February 2024 Abstract The t(X,17) chromosomal translocation, generating the ASPSCR1::TFE3 fusion oncoprotein, is the singular genetic driver of alveolar soft part sarcoma (ASPS) and some Xp11-rearranged r...
- Wed May 08, 2024 5:55 am
- Forum: Personal Stories and Updates
- Topic: Alex from California - Dx Aug 2018 at 19
- Replies: 24
- Views: 8248
Re: Alex from California - Dx Aug 2018 at 19
Janice ,
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- Sun Apr 28, 2024 6:45 am
- Forum: TECENTRIQ (atezolizumab) by Genentech
- Topic: Trial Results Confirm Effectiveness of Atezolizumab Against a Rare Sarcoma
- Replies: 0
- Views: 349
Trial Results Confirm Effectiveness of Atezolizumab Against a Rare Sarcoma
Trial Results Confirm Effectiveness of Atezolizumab Against a Rare Sarcoma https://www.cancer.gov/news-events/cancer-currents-blog/2023/atezolizumab-effective-alveolar-soft-part-sarcoma?fbclid=IwZXh0bgNhZW0CMTEAAR2NPf10qaCY6BCy9mv9aSCF3sFGp5Pfp-AlbEsirCDSbwVTeIAg81-qnb8_aem_AfiuE4UF2G-_0W9lF_4SwvQHj...
- Sat Apr 13, 2024 6:59 am
- Forum: Medical Publications
- Topic: Angiogenesis-Promoting Gene Patterns in Alveolar Soft Part Sarcoma
- Replies: 4
- Views: 3300
Re: Alveolar soft-part sarcoma (ASPS) resembles a mesenchymal stromal progenitor: evidence from meta-analysis of transcr
** Alveolar soft-part sarcoma (ASPS) resembles a mesenchymal stromal progenitor: evidence from meta-analysis of transcriptomic data Alveolar soft-part sarcoma (ASPS) is an extremely rare malignancy characterized by the unbalanced translocation der(17)t(X;17)(p11;q25). This translocation generates a ...
- Fri Apr 12, 2024 9:43 am
- Forum: Other Publications
- Topic: Wnt Signaling in the Development of Bone Metastasis
- Replies: 2
- Views: 359
Re: Wnt Signaling in the Development of Bone Metastasis
2. Wnt in Bone Development and Maintenance As mentioned above, Wnt signaling is a key regulator of developmental and postnatal processes [1,2]. One such process is postnatal bone homeostasis regulation, which is maintained by the delicate balance between bone formation and resorption, which are cont...
- Fri Apr 12, 2024 9:13 am
- Forum: Other Publications
- Topic: Wnt Signaling in the Development of Bone Metastasis
- Replies: 2
- Views: 359
Re: Wnt Signaling in the Development of Bone Metastasis
3. Bone Metastasis Metastasis is the primary cause of mortality in patients with cancer. During cancer development, cancer cells detach from the primary tumor and penetrate the nearby blood and lymphatic vasculature, a process that is called intravasation. From there, they circulate in the blood or...
- Fri Apr 05, 2024 9:31 am
- Forum: Other Publications
- Topic: Wnt Signaling in the Development of Bone Metastasis
- Replies: 2
- Views: 359
Wnt Signaling in the Development of Bone Metastasis
Wnt Signaling in the Development of Bone metastisis Abstract Wnt signaling occurs through evolutionarily conserved pathways that affect cellular proliferation and fate decisions during development and tissue maintenance. Alterations in these highly regulated pathways, however, play pivotal roles in...
- Thu Apr 04, 2024 3:15 pm
- Forum: Other Publications
- Topic: First-ever genetic map to identify causes of sarcoma
- Replies: 0
- Views: 289
First-ever genetic map to identify causes of sarcoma
First-ever genetic map to identify causes of sarcoma
https://health.ucdavis.edu/news/headlin ... er%20arose.
https://health.ucdavis.edu/news/headlin ... er%20arose.
- Thu Apr 04, 2024 3:03 pm
- Forum: Other Publications
- Topic: Roles for Innate Immunity in Combination Immunotherapies
- Replies: 5
- Views: 860
Re: Roles for Innate Immunity in Combination Immunotherapies
innate existing in, belonging to, or determined by factors present in an individual from birth : native, inborn. innate behavior. 2. : belonging to the essential nature of something : inherent. Lymphatic or Hematogenous Dissemination: How Does a Metastatic Tumor Cell Decide? http://www.cureasps.org...
- Sun Mar 31, 2024 3:20 pm
- Forum: Other Publications
- Topic: Roles for Innate Immunity in Combination Immunotherapies
- Replies: 5
- Views: 860
Re: Roles for Innate Immunity in Combination Immunotherapies
The Innate vs. Adaptive Immune Response The first line of defense against non-self pathogens is the innate, or non-specific, immune response. The innate immune response consists of physical, chemical and cellular defenses against pathogens. The main purpose of the innate immune response is to immed...
- Sun Mar 24, 2024 5:42 pm
- Forum: Brain Metastases
- Topic: Scientists identify protein that promotes brain metastasis
- Replies: 6
- Views: 5203
Re: Scientists identify protein that promotes brain metastasis
https://www.sciencedaily.com/releases/2019/11/191104141652.htm “Even when we deleted the CEMIP gene from the cancer cells, providing CEMIP through exosomes restored the molecular environment in brain tissue that allowed the cancer cells to colonize that tissue," said first author Gonçalo Rodri...
- Sun Mar 24, 2024 4:05 pm
- Forum: Brain Metastases
- Topic: Scientists identify protein that promotes brain metastasis
- Replies: 6
- Views: 5203
The Roles of Exosomes in Metastasis of Sarcoma: From Biomarkers to Therapeutic Targets
The Roles of Exosomes in Metastasis of Sarcoma: From Biomarkers to Therapeutic Abstract Sarcoma is a heterogeneous group of mesenchymal neoplasms with a high rate of lung metastasis. The cellular mechanisms responsible for sarcoma metastasis remain poorly understood. Furthermore, there are limited e...
- Wed Mar 20, 2024 8:39 am
- Forum: Medical Publications
- Topic: The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL..
- Replies: 1
- Views: 255
Soft tissue Uncertain differentiation Alveolar soft part sarcoma
Soft tissue
Uncertain differentiation
Alveolar soft part sarcoma
Authors: Laura Warmke, M.D., Jeanne Meis, M.D.
Editorial Board Member: Nasir Ud Din, M.B.B.S.
Deputy Editor-in-Chief: Borislav A. Alexiev, M.D.
https://www.pathologyoutlines.com/topic ... rsoft.html
Uncertain differentiation
Alveolar soft part sarcoma
Authors: Laura Warmke, M.D., Jeanne Meis, M.D.
Editorial Board Member: Nasir Ud Din, M.B.B.S.
Deputy Editor-in-Chief: Borislav A. Alexiev, M.D.
https://www.pathologyoutlines.com/topic ... rsoft.html