Cure Alveolar Soft Part Sarcoma International (iCureASPS)

** Alveolar soft-part sarcoma (ASPS) resembles a mesenchymal stromal progenitor: evidence from meta-analysis of transcriptomic data Alveolar soft-part sarcoma (ASPS) is an extremely rare malignancy characterized by the unbalanced translocation der(17)t(X;17)(p11;q25). This translocation generates a ...

2. Wnt in Bone Development and Maintenance As mentioned above, Wnt signaling is a key regulator of developmental and postnatal processes [1,2]. One such process is postnatal bone homeostasis regulation, which is maintained by the delicate balance between bone formation and resorption, which are cont...

3. Bone Metastasis Metastasis is the primary cause of mortality in patients with cancer. During cancer development, cancer cells detach from the primary tumor and penetrate the nearby blood and lymphatic vasculature, a process that is called intravasation. From there, they circulate in the blood or...

Wnt Signaling in the Development of Bone metastisis Abstract Wnt signaling occurs through evolutionarily conserved pathways that affect cellular proliferation and fate decisions during development and tissue maintenance. Alterations in these highly regulated pathways, however, play pivotal roles in...

First-ever genetic map to identify causes of sarcoma




https://health.ucdavis.edu/news/headlin ... er%20arose.

innate existing in, belonging to, or determined by factors present in an individual from birth : native, inborn. innate behavior. 2. : belonging to the essential nature of something : inherent. Lymphatic or Hematogenous Dissemination: How Does a Metastatic Tumor Cell Decide? http://www.cureasps.org...

The Innate vs. Adaptive Immune Response The first line of defense against non-self pathogens is the innate, or non-specific, immune response. The innate immune response consists of physical, chemical and cellular defenses against pathogens. The main purpose of the innate immune response is to immed...

https://www.sciencedaily.com/releases/2019/11/191104141652.htm “Even when we deleted the CEMIP gene from the cancer cells, providing CEMIP through exosomes restored the molecular environment in brain tissue that allowed the cancer cells to colonize that tissue," said first author Gonçalo Rodri...

The Roles of Exosomes in Metastasis of Sarcoma: From Biomarkers to Therapeutic Abstract Sarcoma is a heterogeneous group of mesenchymal neoplasms with a high rate of lung metastasis. The cellular mechanisms responsible for sarcoma metastasis remain poorly understood. Furthermore, there are limited e...

Soft tissue
Uncertain differentiation
Alveolar soft part sarcoma

Authors: Laura Warmke, M.D., Jeanne Meis, M.D.
Editorial Board Member: Nasir Ud Din, M.B.B.S.
Deputy Editor-in-Chief: Borislav A. Alexiev, M.D.


https://www.pathologyoutlines.com/topic ... rsoft.html

The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25 Alveolar soft part sarcoma (ASPS) is an unusual tumor with highly characteristic histopathology and ultrastructure, controversial histogenesis, and enigmatic clini...

Japanese Journal of Clinical Oncology, Volume 53, Issue 11, November 2023, Pages 1009–1018, https://doi.org/10.1093/jjco/hyad102
Published: 25 August 2023


https://academic.oup.com/jjco/article/5 ... 09/7251339

Abstract Video-assisted thoracic surgery (VATS) has evolved greatly over the last two decades. VATS major lung resection for early stage non-small cell lung carcinoma (NSCLC) has been shown to result in less postoperative pain, less pulmonary dysfunction postoperatively, shorter hospital stay, and b...

“The reaction, discovered in 2017 after four years of research in mice, has been described as a "runaway train" where one error leads the body to develop a very efficient way of attacking itself. The study focussed on B cells gone rogue. Ordinarily these cells produce antibodies and progr...

Key Points Following immunization, CD4+ T cells promote the induction of a robust primary CD8+ T cell response through numerous mechanisms, including licensing of dendritic cells (DCs) and promoting the interaction between DCs and CD8+ T cells. CD4+ T cells regulate the secondary responsiveness of ...