Cure Alveolar Soft Part Sarcoma International (iCureASPS)

Non-mutational neoantigens in disease Abstract The ability of mammals to mount adaptive immune responses culminating with the establishment of immunological memory is predicated on the ability of the mature T cell repertoire to recognize antigenic peptides presented by syngeneic MHC class I and II m...

https://www.google.com/search?q=p53+mutation+and+autoimmune+disease&client=safari&sca_esv=708ca891a389fdf3&sca_upv=1&hl=en-us&ei=1FPiZpugOsHBp84PoP6A0Q4&oq=p53+mutation+and+autoi&gs_lp=EhNtb2JpbGUtZ3dzLXdpei1zZXJwIhZwNTMgbXV0YXRpb24gYW5kIGF1dG9pKgIIADIFECEYoAEyBRAhGKABMgU...

Don't talk to me of fame and fortune Don't tell me of the things you've read Don't get involved in games of reason There ain't no reason I could see for you to win [Chorus] I've asked you questions now for far too long I'm feelin' highly wasted but there ain't no sun I'm tired of callin' you here wh...

“The cyclin D1-mediated secretion of pro-tumorigenic immuno-miRs and piRNAs may contribute to breast tumor initiation and progression. By up-regulating CTNNB1 and CCND1, PIWIL2 can promote cell cycle and proliferation in tumor cells. Cyclin D1 expression and novel mutational findings in Rosai-Dorfma...

https://cureasps.org/forum/viewtopic.php?f=2&t=1390&p=10710&hilit=Constitutional# Oncologist report Dear Editor, DNA mismatch repair (MMR) is a system for recognizing and repairing errors, which occur during DNA replication and recombination. Biallelic deleterious germline mutations in M...

Found this interesting Second paragraph in discussion “There has been one published case of primary ASPS in the bladder, positive for the ASPSCR1-TFE3 fusion, which was diagnosed in a 25-year-old woman with no previous cancer history [2]. This patient case is an exceedingly rare instance of ASPS as...

https://aacrjournals.org/cancerres/article/84/14/2247/746376/ASPSCR1-TFE3-Drives-Alveolar-Soft-Part-Sarcoma-by Alveolar soft part sarcoma (ASPS) is a rare mesenchymal malignancy driven by the ASPSCR1::TFE3 fusion. A better understanding of the mechanisms by which this oncogenic transcriptional regul...

An additional strategy is being used to prevent the onset of disease; this involves the study of pregnancy and early postnatal life. Both of these states are chiefly viewed as Th2 phenomena (to reduce the risk of miscarriage, a strong Th2 response is necessary to modify the Th1 cellular response in...

Is it possible that ASPS is hormone sensitive?
How could it not be with all the roles that hormones play in a persons body .

It still intrigues me to this day.

https://cureasps.org/forum/viewtopic.php?p=7301#p7301

Pseudo-Progression With Cancer Treatment When cancer only appears to worsen on checkpoint inhibitors Pseudoprogression describes when cancer appears to get worse when it is actually improving. This can lead some individuals to stop their cancer treatment early. With the exception of a type of brain ...

Advances in the development of personalized neoantigen-based therapeutic cancer vaccines


https://www.nature.com/articles/s41571-020-00460-2

Alveolar Soft Part Sarcoma ASPS is a very distinct entity as evidenced by the unique set of antigens we report as top 25 hits, many of which are not shared with other tumors. EPOR, the erythropoietin receptor, was the highest-ranking hit for ASPS. The ETV6-RUNX1 fusion in ALL activates transcriptio...

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Immunoprofiling in alveolar soft part sarcoma.

https://ascopubs.org/doi/abs/10.1200/JC ... uppl.11059