The 13th PMC Bike Ride of “Team ASPS” and the Upcoming 14th Ride: Please Support Our Efforts to Find a Cure for ASPS

On August 6 – 7 2016, “Team ASPS” participated for the 13th time in the Pan-Massachusetts Challenge (PMC) bike ride. This bike-a-thon crosses Massachusetts to raise money for cancer research and treatment at the Dana-Farber Cancer Institute (DFCI) in Boston. Our team rode 163 miles and raised $49,117 specifically dedicated for finding a cure for ASPS.

Registration for the 2017 PMC bike ride is now open and we would like to encourage you to help us with fundraising and joining our team.

Donations will continue to support the efforts of Dr. George Demetri, Dr. Andrew Wagner and Dr. Ewa Sicinska to identify novel drugs and initiate new clinical trials for ASPS patients.

We will continue to update you on the results of these efforts as well as on ASPS research and clinical trials elsewhere.

We thank “Team ASPS”, our donors and to the ASPS community for all the relentless support for our efforts to find a cure for ASPS.

Below are Photos taken during the 2016 PMC bike ride.

Thank you for your support!

_____________________________________________________

Yosef Landesman, Ph.D.
President & Cancer Research Director
Cure Alveolar Soft Part Sarcoma International (iCureASPS)
e-mail: landesmany@yahoo.com

Donation for ASPS Research in Honor of Kevin Kanai Griffith

iCureASPS thanks Liz Cooper, “Gamers For Good” and all the wonderful donors for the very generous donation of $15,000 aimed towards finding a cure for Alveolar Soft Part Sarcoma (ASPS). This donation helps to extend the collaboration of iCureASPS with the Dana Farber Cancer Institute in Boston, which has been ongoing since 2004.

Liz Cooper, President and Co-Founder of Gamers For Good, collected this donation through an 18-month art-book campaign. The campaign honored Kevin Kanai Griffith who was suffering from ASPS and sadly passed in October 2014.

The donation arrived just as we began plans for our 2016 research efforts.

Gamers for Good is a registered 501(c)(3) charity. Its mission is to provide charitable assistance to educate the general public about game development as a positive part of our society.
_____________________________________________________

Yosef Landesman, Ph.D.
President & Cancer Research Director
Cure Alveolar Soft Part Sarcoma International (iCureASPS)
e-mail: landesmany@yahoo.com

This Weekend Team ASPS Participated for the 12th Time in the PMC Bike Ride and Continues to Raise Funds to Sponsor Research on ASPS at the Dana Farber Cancer Institute in Boston

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Dear ASPS community, this weekend (August 1-2) Team ASPS participated for the 12th time in the Pan-Massachusetts Challenge (PMC).This is a bikea
thon that crosses Massachusetts to raise money for cancer research and clinical trials at the Dana-Farber Cancer Institute in Boston. Donations for Team ASPS are restricted for research on ASPS only.

I would like to remind that in 2005, following Team ASPS second ride we were able to initiate the GVAX cancer vaccine trial, which was developed by Dr. Glenn Dranoff. This was the first clinical trial ever that was dedicated for this very rare cancer.

We continue the research with Dr. George Demetri, Dr. Andrew Wagner, Dr. Massimo Loda and Dr. Ewa Sicinska at the Dana Farber. Those donations are helping us to learn more about ASPS and also
to inspire others in other research institutes to study ASPS. Our goal is to find the cure for our loved ones.

Please help us to find a cure for ASPS and please donate!
We are using our restricted account of the PMC for the collection of donation.

To donate online through the PMC website:

Please click on the following link: http://www.pmc.org/profile/YL002
This is Yosef Landesman ride page on the PMC website. Once you are on my personal page, click on “DONATE TO MY RIDE“.

Your donation is a fully tax refundable. The PMC tax ID is 04-2746912

Please let me know if you have any question. I thank you for your support.

Best Wishes, Yossi

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_____________________________________________________

Yosef Landesman, Ph.D.
President & Cancer Research Director
Cure Alveolar Soft Part Sarcoma International (iCureASPS)
e-mail: landesmany@yahoo.com

Thank You Somerset Middle School!

Dear iCureASP Community,

I would like to thank the special students and teachers at Somerset Middle School in Wisconsin for their act of kindness and generosity. They made a decision to support the search for the much needed cure for Alveolar Soft Part Sarcoma.

Recently in my mailbox I found a donation with the following kind letter:

“Dear iCureASPS,

The students in my Family and Consumer Science class have a lab in which they are learning to measure and read a receipt. I have them make cookies and bars. Instead of eating them all we have a bake sale for the middle school students. The kids take a vote as to where the money will go. My class decided to have the proceeds from our bake sale go to iCureASPS, to help with research. One of my student’s brother does have this rare form of Cancer. Enclosed you will find a check for $397.45. Please use it to help wherever it is needed.

Sincerely,

Debbie Stevens
Somerset Middle School Family and Consumer Science Teacher”.

Special thanks to Sara Eichten, Principal of Somerset Middle School and to the parents who teach and educate their children to show good citizenship by actively performing acts of kindness.

Photo Somerset Middle School copy
______________________________________________________

Yosef Landesman, Ph.D.
President & Cancer Research Director
Cure Alveolar Soft Part Sarcoma International (iCureASPS)
e-mail: landesmany@yahoo.com

Donate now and support the development of cure for ASPS

We are opening iCureASPS annual fundraiser with the traditional PMC bike ride. Our ASPS team rides yesterday and today for the 10th year at the Pan-Massachusetts Challenge (PMC). Ten years have passed since we founded our group and started to look for a cure for Alveolar Soft Part Sarcoma (ASPS), a rare cancer that has no cure and affects mainly young people.

The PMC is a bike-a-thon that crosses Massachusetts to raise money for cancer research and clinical trials at the Dana-Farber Cancer Institute in Boston. Members in our team ride this year 50, 90 or 140 miles between Wellesley to Cape Cod. Team ASPS set-up a restricted fund within the PMC. This restricted fund is aimed to achieve breakthrough in research and cure for Alveolar Soft Part Sarcoma.

Our goal this year is to initiate a new human clinical trial for ASPS patients in 2014 and WE NEED YOUR SUPPORT.

Team ASPS and iCureASPS already demonstrated that collaboration with the Dana Farber Cancer Institute is fruitful. Our collaboration resulted at the first ASPS clinical trial in 2005. This was the GVAX cancer vaccine clinical trial, which is under development by Dr. Glenn Dranoff.

Currently we are collaborating also with Dr. George Demetri, Dr. Andrew Wagner, Dr. Massimo Loda and Dr. Ewa Sicinska.

We hope to announce in 2014 the availability of a new clinical trial using a novel anti-cancer therapy.

There are two convenient ways to donate:
1. Online donations through the PMC website: Please click on the following link: Yosef Landesman ride page on the PMC website: (http://www.pmc.org/profile/YL0002). Then, once you are on my personal page, click on “DONATE TO MY RIDE”.

2. You can write a check payable to “PMC-Team ASPS YL0002”. Mail the check to:
Yosef Landesman
260 Tappan St.
Brookline, MA 02445

Your donation is a fully tax refundable. The PMC tax ID is 04-2746912
From the bottom of my heart I thank you for your support.

Best Wishes,
Yosef Landesman
______________________________________________________

Yosef Landesman, Ph.D.
President & Cancer Research Director
Cure Alveolar Soft Part Sarcoma International (iCureASPS)
e-mail: landesmany@yahoo.com

The 9th PMC bike ride of “Team ASPS”: More donations for preclinical studies of Alveolar Soft Part Sarcoma

On the first weekend of August 2012, “Team ASPS” participated for the 9th time in the Pan-Massachusetts Challenge (PMC) bike ride. This bike-a-thon crosses Massachusetts to raise money for cancer research and treatment at the Dana-Farber Cancer Institute (DFCI) in Boston. Our team rode 90 miles and raised $30,705 specifically dedicated for finding a cure for ASPS.

Donation this year will specifically support preclinical testing of novel drugs for the cure of ASPS.
Dr. George Demetri, Dr. Andrew Wagner, Dr. Massimo Loda and Dr. Ewa Sicinska at the Dana Farber Cancer Institute in Boston conduct those preclinical studies and reserach.

I will continue to update you here on this website on the results of those efforts that were initiated almost 10 years ago.

Cure ASPS International thanks “Team ASPS”, our donors and to the ASPS community for all the relentless support for our efforts to find a cure for ASPS.

Below are Photos taken during the 2012 PMC bike ride. Best wishes for a Happy New Year!

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______________________________________________________

Yosef Landesman, Ph.D.
President & Cancer Research Director
Cure Alveolar Soft Part Sarcoma International (iCureASPS)
e-mail: landesmany@yahoo.com

Support Research of ASPS: A Novel Mouse Tumor Model

In collaboration with iCureASPS, Dr. George Demetri, Dr. Massimo Loda, and Dr. Ewa Sicinska at the Dana Farber Cancer Institute in Boston have started a new initiative that aims to find an effective therapy for Alveolar Soft Part Sarcoma. This research will make use of a cell line that was established from a tumor taken out of an ASPS patient. This cell line grows into a tumor when transplanted into mice, and has the characteristics of an ASPS tumor (see figure). It will be used as a tool to search for effective drugs against ASPS. 

  Please read the description below and help us raise the needed funds for this project!

Dr. Ewa Sicinska conducts the research. She explains:

“Our goal is to establish a mouse xenograft model, which could be used for pre-clinical trials without the involvement of patients. First, we injected the ASPS cell line into mice. After the tumors grew, we subcutaneously transplanted small fragments of tumor into recipient Nu/Nu mice. Currently, we’ve transplanted tissue into passage 2 mice*. Histopathology of the tumors generated in subsequent passages revealed that the morphology of the tumors doesn’t change, and is identical to the appearance of tumors in humans. We are planning to implant these tumors into multiple recipients, and use them for treatment with new drugs.

* this means the tumor has been propagated from mouse to mouse, and currently is growing in the second round of mice – this is a measure of robustness of the system.

In August 2011, Team ASPS will ride for the 8th time the Pan-Massachusetts Challenge (PMC). The PMC is a bike-a-thon that crosses Massachusetts to raise money for cancer research and clinical trials at the Dana-Farber Cancer Institute in Boston.

Team ASPS will dedicate this year’s PMC fund raiser to support the development of this new and promising ASPS tumor model research project. 

In the past 7 years through the efforts of Team ASPS and iCureASPS, we raised and transferred nearly $300,000 exclusively for ASPS research programs at the Dana Farber and also to other research institutions in the US and the world. Thanks to those efforts, the first “Cancer Vaccine” Clinical Trial (GVAX) to treat ASPS was opened in January 2005. This clinical trial was followed by the ARQ197 clinical trial, and now by the Cediranib clinical trial

There are two convenient ways to donate:

1. Online donations through the PMC website: (http://www.pmc.org/).  In the upper left box, please type my name: “Yosef Landesman” and click “find”. Then click on my name and “donate to my ride”. You can also donate to any of the riders in Team ASPS, or directly donate to the Team.

2. You can write a check payable to “PMC-Team ASPS YL0002”.  For address, please contact me by using my e-mail address below.  

Your donation is fully tax deductible. The PMC tax ID is 04-2746912.

I thank you for your support.

______________________________________________________

Yosef Landesman, Ph.D.
President & Cancer Research Director
Cure Alveolar Soft Part Sarcoma International (iCureASPS)
e-mail:
landesmany@yahoo.com

 

The Third Annual Knockin’ Down ASPS Event in the memory of Anthony Salisbury (AJ)

The third annual Knockin’ Down ASPS Event in the memory of Anthony Salisbury (AJ) took place in May. This year, over $12,000 was raised and donated directly to the laboratory of Dr. Glenn Dranoff at the Dana Farber Cancer Institute in Boston to support his efforts in finding a cure for Alveolar Soft Part Sarcoma.

Cure Alveolar Soft Part Sarcoma International, and the Alveolar Soft Part Sarcoma community extend our thanks to the Knockin’ Down ASPS committee, participants, and donors. Special thanks and wishes to Kim. Your support enables progress towards the so much needed ASPS cure!

______________________________________________________

Yosef Landesman, Ph.D.
President & Cancer Research Director
Cure Alveolar Soft Part Sarcoma International (iCureASPS)
e-mail:
landesmany@yahoo.com

Register Now to Join Team ASPS in the 2011 PMC Bike Ride

Since its inception, the iCureASPS organization has transferred more than a quarter million dollars to keep up research, and clinical trials that aim to find a cure for ASPS. I would like to thank the ASPS community, friends, and family who are supporting us in our goal of finding a cure for ASPS.

Please make a new year resolution now to continue helping us to reach our goal of eradicating ASPS. Help us locate research centers which would join our quest for a cure, and then organize a fund raiser where the donations will be sent directly to the research institution of your choice. Alternatively, join the Team ASPS fund raiser, and our PMC bike ride in Massachusetts this summer!

The registration for the 2011 PMC bike ride is now open. The ride will take place on August 6 and 7. This year marks the 8th time Team ASPS will participate in the ride. We are looking for more riders to join our team. The PMC is a bike-a-thon that crosses Massachusetts to raise money for cancer research and clinical trials at the Dana-Farber Cancer Institute in Boston. Donations, raised by Team ASPS, are restricted for research and clinical trials that aim to find a cure for Alveolar Soft Part Sarcoma.

You can join us as a rider, or as a virtual rider. If you cannot join, us please consider sponsoring our team. The PMC has a nonprofit organization status and donors will receive PMC receipts.

Please do not hesitate to contact me with question and ideas.

______________________________________________________

Yosef Landesman, Ph.D.
President & Cancer Research Director
Cure Alveolar Soft Part Sarcoma International (iCureASPS)
e-mail:
landesmany@yahoo.com

Tumor Expression Profile of Alveolar Soft Part Sarcoma May Pave the Way for New Treatments at The Dana Farber Cancer Institute

Scientists from the group of Dr. Massimo Loda reported the results of an extensive study that aims to identify potential therapeutic targets for ASPS last Friday.

The research team, comprised of Shamini Selvarajah (PhD), Eleanor Chen (MD, PhD), and Saumyadipta Pyne (PhD), used cDNA microarray technology (gene expression array) to examine the expression of 18,401 genes in primary, and metastatic ASPS tumors from 14 ASPS patients. The work was done in collaboration with Brigham and Women’s Hospital, and the Broad Institute, affiliated with the Massachusetts Institute of Technology, and Harvard University.

Significant gene expression changes were discovered in 1,063 genes. The team elected to focus on 323 of them, which were singled out for their dramatically increased (or decreased) expression from the time the ASPS tumor was a primary (original tumor) to the time it turned into a metastasis. In other words, this work identified genes (those genes turn into proteins in the tumor) that changed their expression, as the tumor increased in aggressiveness. Such genes are well suited to be targeted as a therapeutic modality. Initial analysis of those genes points to several known molecular pathways that contribute to tumor growth and angiogenesis (formation of new blood vessels) in other types of cancers. The next challenge will be to identify the most promising target genes, for which approved drugs already exist. As an initial next step, these drugs could then be tested in animal tumor models of ASPS, and in ASPS cell lines.

Dr. Glenn Dranoff is an active participant, and collaborator in this project. Dr. Dranoff developed the GVAX vaccine, and ran the first GVAX clinical trial for ASPS patients. He will continue to be involved in the efforts to find a cure for ASPS.

Dear ASPS patients, friends and family members! We need your help to continue supporting the science behind results like this one. Through cutting edge research, more groundbreaking findings will be made that will bring a cure for ASPS. You can help, and be part of these great efforts.

Please:

1.   Consider fund-raising and donations to support the efforts to find a cure for ASPS at the Dana-Farber Cancer Institute.

2.   Encourage patients who are planning surgeries to donate their tumors to the Dana Farber.

3.   Communicate with me in regards to both of the above to ensure that funds and tumor donations reach their destination.

We are thankful to Dr. Massimo Loda and the scientists who did this important work, Dr. Glenn Dranoff, Dr. Ewa Sicinska, and the administrative staff Marcia Izzi and Laurie Peterson.

iCureASPS will continue to support these studies through direct funding, and through Team ASPS with the Pan Mass Challenge, as we believe that this is the way to discover the much needed cure!

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______________________________________________________

Yosef Landesman, Ph.D.
President & Cancer Research Director
Cure Alveolar Soft Part Sarcoma International (iCureASPS)
e-mail:
landesmany@yahoo.com