Dr. David Vistica, and his collaborators from the National Cancer Institute (in Frederick, MD), published the results from their analysis of gene expression in donated ASPS tumors. It identified elevated expression of genes, related to cancer. These may have diagnostic and therapeutic potential. Few examples are:
- Involved in angiogenesis: ANGPTL2, HIF-1 alpha, MDK, c-MET, VEGF, TIMP-2.
- Involved in cell proliferation: PRL, IGFBP1, NTSR2, PCSK1
- Involved in metastasis: ADAM9, ECM1, POSTN
- Involved in steroid biosynthesis: CYP17A1, STS.
So far, the cell origin of ASPS was not clear. The study identifies the muscle-restricted gene expression as ITGB1, BP3/MIBP, MYF5, MYF6 and TRIM63. This strengthens the hypothesis that the primary ASPS tumor develops from muscle cell progenitor.
The full paper, including all genes found to be expressed in ASPS, is available here.
Yosef Landesman, Ph.D.
President & Cancer Research Director
Cure Alveolar Soft Part Sarcoma International (iCureASPS)